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Scientist I/II, In Vivo Pharmacology
Full Time
Boston, Massachusetts, United States
Sponsors work visa for candidates.
Job description
Scismic is supporting the growth of a clinical stage biotech company in Boston, MA!
We are seeking an experienced in vivo oncology scientist I/II to contribute to progressing our research projects. This position is within our Cancer Biology team, a group whose mission is to discover, evaluate, and develop novel therapeutics. The successful candidate will bring a sense of urgency and commitment to support our research programs and deliver novel patient-directed therapies to patients.
We are seeking an experienced in vivo oncology scientist I/II to contribute to progressing our research projects. This position is within our Cancer Biology team, a group whose mission is to discover, evaluate, and develop novel therapeutics. The successful candidate will bring a sense of urgency and commitment to support our research programs and deliver novel patient-directed therapies to patients.
Your Role
- Work closely with project teams to identify and develop mouse tumor models that align with program targets of interest
- Independently design and conduct in vivo efficacy, PK/PD, and tolerability studies in mouse models to support research projects; perform dosing, blood/tissue collection, and necropsy in adherence to IACUC policies and protocols
- Perform in vitro and ex vivo assays (e.g. qPCR, western blot, cytotoxicity) to define PD/efficacy relationships
- Provide analysis and interpretation of data with clear communication in cross-functional project team meetings, highlighting implications for the broader programs; contribute to high-level decision-making
- Engage with CROs and manage out-sourced in vivo studies
- Maintain accurate, timely, and complete electronic laboratory notebook entries; prepare study protocols, reports, and regulatory documents as needed
- Proactively review literature to bring in the newest scientific findings, ideas, and methods/technologies for research
- Support the organization by maintaining a work environment focused on scientific integrity that fosters learning, open communication, and collaboration
- Serve as a mentor and technical resource for junior scientists
- Additional duties and responsibilities as required
Your Qualifications
- PhD in Biology, Pharmacology, Biomedical Sciences or related discipline and 2 years of post-doctoral experience, OR
- Master’s degree with at least 8 years of relevant experience in a biotechnology or pharmaceutical company; 4+ years of in vivo experience in industry or academic setting
- Broad knowledge across multiple disciplines including cancer biology and pharmacology; hands-on experience applying pharmacology knowledge and principles of PK, PD, and ADME to support drug development through lead optimization to candidate selection
- Track record of scientific contribution across projects to support project advancement
- Demonstrated experience with in vivo oncology models, including CDX, PDX, and syngeneic mouse models
- Proficiency in animal dosing (SC, PO, and IP routes of administration), tumor monitoring, and necropsy
- Experience with aseptic cell culture technique, and cell and molecular biology assays (including qPCR and western blot) required
- The successful candidate will be a motivated self-starter, with strong communication skills and the ability to work in a fast-paced, team-oriented environment