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Senior Scientist, Analytical Chemistry
Full Time
Greater Boston area, Massachusetts, United States
Job description
Scismic is supporting the growth of a biotech company in the Greater Boston area!
We are seeking an energetic, dedicated, highly motivated and creative protein chemist to design and synthesize novel drug like proteins and peptides, develop methods for producing various protein conjugates, modifications, purification, analytical method development for characterization to support our drug product development platform. The senior scientist will be responsible for developing synthesis, formulation, and analytical methods needed to develop novel drug product candidates to enable animal testing and boost our pipeline. In addition, the role will require optimization of analytical methods, synthetic process development, specification development and technical transfer of processes and methods to GMP facilities at external partners. This role will contribute significantly towards the drug product development platform and research activities within our company.
We are seeking an energetic, dedicated, highly motivated and creative protein chemist to design and synthesize novel drug like proteins and peptides, develop methods for producing various protein conjugates, modifications, purification, analytical method development for characterization to support our drug product development platform. The senior scientist will be responsible for developing synthesis, formulation, and analytical methods needed to develop novel drug product candidates to enable animal testing and boost our pipeline. In addition, the role will require optimization of analytical methods, synthetic process development, specification development and technical transfer of processes and methods to GMP facilities at external partners. This role will contribute significantly towards the drug product development platform and research activities within our company.
ROLES AND RESPONSIBILITIES:
- Design, chemical synthesis, purification and characterization of proteins, peptides and analogs for drug product development
- In process optimization for chemical synthesis, purification and analytical characterization methods for the drug product
- Protein Analysis of the drug product for animal studies
- Tech transfer of synthesis, purification and analytical methods to CDMOS/CROs
- Documenting all the experimental methods and lab activities
- Comply with appropriate biosafety and regulatory requirements
- Assist Director/Principal scientist in various scientific projects
QUALIFICATIONS:
- Master’s or PhD degree in Organic Chemistry, Medicinal Chemistry or related fields
- At least 6+ years of working experience in a laboratory setting (Academia or Industry) and conducting various physicochemical experiments related drug development and formulation
- Deep experience with protein synthesis, purification, modification, and analytical methods for sequence analysis
- Experience with advanced analytical instrument/methods such as RP-HPLC, SPR, AUC, DLS, UV-Vis Spectrophotometry, LC-MS, NMR, Lyophilization, TFF concentration/Diafiltration, amino acid analyses
- Experience with Microsoft Word and Excel, PowerPoints, graphing software (GraphPad prism/Origin etc.)
- Strong verbal and written communication skills
- Strong organizational skills, attention to detail, and a strong work ethic
- Ability to work well in a multidisciplinary team-based environment and interact with individuals of various backgrounds and levels within the company
- Ability to learn and adapt to new tools and techniques related to the work